United States securities and exchange commission logo January 12, 2024 Wensheng Fan Chief Executive Officer Spectral AI, Inc. 2515 McKinney Avenue, Suite 1000 Dallas, TX 75201 Re: Spectral AI, Inc. Registration Statement on Form S-1 Filed January 5, 2024 File No. 333-276406 Dear Wensheng Fan: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Benjamin Richie at 202-551-7857 with any questions. Sincerely, Division of Corporation Finance Office of Industrial Applications and Services cc: Herbert F. Kozlov